WHOs klassifisering fra 2022 innføres. Akselerert fase er avskaffet. I blastfase er grensen satt til 20% myeloblaster og >5% lymfoblaster i PB eller BM Dette betyr at resultater fra tidligere studier på blastfase og akselerert fase ikke nødvendigvis er fullt dekkende for pasienter som klassifiseres etter den nye definisjonen
Start med Tyrosin kinase hemmer (TKI) på morfologisk sterk mistanke om kronisk myelogen leukemi (KML). Ikke bruk hydroxyurea eller allopurinol. Pasientene bør oppfordres til rikelig væskeinntak første måned.
Asciminib er innført av Nye metoder til behandling av Philadelphia- kromosom-positiv kronisk myelogen leukemi i kronisk fase (Ph+KML-KF) som tidligere er behandlet med to eller flere tyrosinkinasehemmere (TKIer), hvor rimeligere tyrosinkinasehemmere ikke er egnet.
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